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博士&硕士生导师

闫兵

                                             

闫兵

博士,教育部长江学者特聘教授

山东大学环境科学与工程学院, 博导

E-maildrbingyan@yahoo.com

 

教育背景

1978.02-1982.01 山东大学化学系,学士

1986.09-1989.10 美国哥伦比亚大学,M.A.

1986.09-1990.10 美国哥伦比亚大学,M.Phil.

1989.09-1990.10 美国哥伦比亚大学,Ph.D.

 

研究方向

环境毒理与健康

 

发表论文、专著、专利及奖励

出版英文专著11部,并在Nature NanotechnologyChemical ReviewsChemical Society ReviewsNature CommunicationsJournal of the American Chemical SocietyNano LettersACS NanoAdvanced Functional MaterialsEnvironmental Science & Technology等学术期刊上发表论文270余篇(详见团队网站:http://www.yanlab.net)。

学术兼职

1. Ecotoxicology and Environmental Safetyby Elsevier)共同主编

2. NanoImpactby Elsevier)副主编(2016年至今)

3. 美国化学会"ACS Combinatorial Sciences (J Comb Chem)"编委(1999-2005)及副主编(2005-2011

科研项目:

1. 国家重点研发计划纳米专项:水污染治理所用纳米材料的生物安全性(课题编号:2016YFA0203103,执行年限:2016.07-2021.06

2. 国家自然科学基金重大研究计划重点项目:细颗粒物与生物界面作用机制的系统探索(项目编号:915432042016-2019年)

3. 国家自然科学基金重大研究计划重点项目:非编码RNA在大气细颗粒物致气道炎症反应中的作用机制研究(项目编号:916432042016-2020年)

4. 中国科学院B类战略性先导科技专项:典型污染物的环境暴露与健康危害机制,协作课题细颗粒物引起细胞氧化应激及免疫毒性的机制及健康效应关联(项目编号:XDB140304012014-2019年)

5. 国家重大基础研究(973)课题:目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价(项目编号:2010CB933504,2010-2014

6. 国家自然科学基金重点项目:典型纳米材料的生物毒性效应及调控研究(项目编号:211370022012-2016年)

7. 国家自然科学基金面上项目:环境中碳纳米管生物毒性的分子机制与调控研究(项目编号:210770682011-2013年)

8. 国家自然科学基金重大研究计划培育项目:选择性治疗耐药性肺癌的噻唑烷酮类小分子探针化合物的设计、合成及其体内外抗癌活性研究与机制探讨(项目编号:909130062010-2012年)

近期代表性论文:

1. Bai, X., Wang, S., Yan, X., Zhou, H., Zhan, J., Liu, S., Sharma, V. K., Jiang, G., Zhu, H., Yan, B.*, Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries. ACS Nano 2020, 14, (1), 289-302.

2. Yan X., Sedykh A., Wang W., Yan B.*, Zhu H.* Construction of a web-based nanomaterial database by big data curation and modeling friendly nanostructure annotations. Nature Communications. 2020. In press.

3. Jia, H., Li, S., Wu, L., Li, S., Sharma, V. K., Yan, B.*, Cytotoxic Free Radicals on Air-Borne Soot Particles Generated by Burning Wood or Low-Maturity Coals. Environmental Science & Technology. 2020. In press.

4. Zhou, X., Jia, J., Luo, Z., Su, G., Yue, T., Yan, B.*, Remote Induction of Cell Autophagy by 2D MoS2 Nanosheets via Perturbing Cell Surface Receptors and mTOR Pathway from Outside of Cells. ACS Applied Materials & Interfaces 2019, 11, (7), 6829-6839.

5. Pan, X., Yuan, X., Li, X., Gao, S., Sun, H., Zhou, H., Hou, L., Peng, X., Jiang, Y.*, Yan, B.*, Induction of Inflammatory Responses in Human Bronchial Epithelial Cells by Pb2+-Containing Model PM2.5 Particles via Downregulation of a Novel Long Noncoding RNA lnc-PCK1-2:1. Environmental Science & Technology 2019, 53, (8), 4566-4578.

6. Wang W, Sedykh A, Sun H, Zhao L, Russo D, Zhou H, Yan B*, Zhu H*. Predicting Nano-bio Interactions by Integrating Nanoparticle Libraries and Quantitative Nanostructure Activity Relationship Modeling. ACS Nano. 2017. 11 (12) :12641–12649.

7. Zhang Y, Wang Y, Liu A, Xu L, Zhao B, Zhang Y, Zou H, Wang W, Zhu H and Yan B.*, Modulation of Carbon Nanotube’s Perturbation to the Metabolic Activity of CYP3A4 in the Liver, Advanced Functional Materials 2016, 26:841-850.

8. Wu L, Zhang Y, Zhang C, Cui X, Zhai S, Liu Y, Li C, Zhu H, Qu G, Jiang G, Yan B.* Tuning Cell Autophagy by Diversifying Carbon Nanotube’s Surface Chemistry. ACS Nano, 2014, 8(3): 2087-99.

9. Mu Q, Jiang G, Chen L, Zhou H, Fourches D, Tropsha A & Yan B.*, Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems. Chemical Reviews 2014, 114(15):7740-81.

10. Zhang Y, Bai Y, Jia J, Gao N, Li Y, Zhang R, Jiang G, Yan B.*, Perturbation of Physiological Systems by Nanoparticles. Chemical Society Reviews 2014, 28(3):296-305.

11. Wang Y, Yan B, Chen L. SERS Tags: Novel Optical Nanoprobes for Bioanalysis. Chemical Reviews 2013, 113(3), 1391-1428.

12. Li L, Zhang Q, Liu A, Li X, Zhou H, Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. Journal of the American Chemical Society 2011, 133(18), 6886-6889.

13. Gao N, Zhang Q, Mu Q, Bai Y, Li L, Zhou H, Butch E, Powell T, Snyder S, Jiang G, Yan B*, Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity. ACS Nano 2011, 5(6), 4581-4591.

14. Zhou H, Jiao P, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. Journal of the American Chemical Society 2011, 133(4), 680-682.

15. Jiao P, Zhou H, Otto M, Mu Q, Li L, Su G, Zhang Y, Butch E, Snyder S, Jiang G, Yan B.* Leading Neuroblastoma Cells to Die by Multiple Premeditated Attacks from a Multifunctionalized Nanoconstruct. Journal of the American Chemical Society 2011, 133(35), 13918-13921.

16. Bai Y, Zhang Y, Zhang J, Mu Q, Zhang W, Butch E, Snyder S, Yan B.* Repeated carbon nanotube administrations in male mice cause reversible testis damage without affecting fertility. Nature Nanotechnology 2010, 5(9), 683-689.

17. Mu Q, Du G, Chen T, Zhang B, Yan B.* Suppression of Human Bone Mophorgenetic Protein (BMP) Signaling by Carboxylated Single-Walled Carbon Nanotubes. ACS Nano 2009, 3(5), 1139-1144.

18. Mu Q, Broughton D, Yan B.* Endosomal Leakage and Nuclear Translocation of Multiwalled Carbon Nanotubes: Developing a Model for Cell Uptake. Nano Letters 2009, 9(12), 4370-4375.

19. Zhang B, Xing Y, Zhou H, Li Z, Mu Q, Yan B.* Functionalized Carbon Nanotubes Specifically Bind to Chymotrypsin Catalytic Site and Regulate its Enzymatic Function. Nano Letters 2009, 9(6), 2280-2284.

20. Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B*. A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Letters 2008, 8(3), 859-865.

 

代表性专著:

1. Yan, B., Zhou, H. Gardea-Torresdey, J. (2017) Bioactivity of Engineered Nanoparticles by Springer-Nature.

2. Yan, B., Zhang, B. (2010) Analytical methods in combinatorial chemistry, Second Edition by Francis and Taylor Group.

3. Yan, B. and Czarnik, AW, Series Editors (2009) Critical Review in Combinatorial Chemistry Volume 5. Chen, T. High-Throughput Screening Technologies by Francis and Taylor Group.

4. Yan, B. and A. W. Czarnik, Series Editors (2008) Critical Review in Combinatorial Chemistry Volume 4. Wang, P. High-Throughput Analysis in Pharmaceutical Industry by Francis and Taylor Group.

5. Yan, B. and A. W. Czarnik, Series Editors (2008) Critical Review in Combinatorial Chemistry Volume 3. Tushar A. Kshirsagar Editor, High-Throughput Lead Optimization in Drug Discovery. by Francis and Taylor Group.

6. Yan, B. and A. W. Czarnik, Series Editors (2005) Critical Review in Combinatorial Chemistry Volume 2. Armen M. Boldi, Editor, Combinatorial Synthesis of Natural Product Based Libraries. by Francis and Taylor Group.

7. Yan, B. and A. W. Czarnik, Series Editors (2005) Critical Review in Combinatorial Chemistry Volume 1. Radislav A. Potyrailo, Wilhelm Maier. Editors, Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials. by Francis and Taylor Group.

8. Yan, B. Editor (2003) Chemical Analysis – A Series of Monographs on Analytical Chemistry and Its Applications Volume 163 “Analytical and purification methods in Combinatorial Chemistry”by John Wiley and Sons, Inc. Highlighted by:Journal of Natural Products, 2004, Vol. 67, No. 6, 1076.Angew. Chem. Int. Ed. 2004, 43, 4552 –4553. Drug Development And Industrial Pharmacy, 2004, Vol. 30, No. 7, p. 793.

9. Yan, B. and Czarnik, A. Editors (2001) Optimization of solid-phase combinatorial synthesis by Marcel Dekker, New York. Highlighted by J. AM. CHEM. SOC. 9 VOL. 124, NO. 26, 2002 7875.

10. Gremlich, H. U. and Yan, B. Editors (2000) Biological FTIR and Raman Spectroscopy by Marcel Dekker, New York. Highlighted by J. Am. Chem. Soc., Vol. 123, No. 42, 2001 10427.

11. Yan, B. (1999) Analytical methods in combinatorial chemistry by CRC Press (former Technomics). Highlighted by Journal of Medicinal Chemistry, 2001, Vol. 44, No. 20, 3334.

 

授权专利:

1. 一种抗肺癌的药物组合物。已授权;授权公告日期:20111116日;专利号:ZL 2010 1 0115656. X

2. 2-苯醚基亚氨基-5-(2-羟基-苯甲基)-1, 3-噻唑-4-酮在制备抗脑癌药物中的应用。已授权;授权公告日期:2011119日;专利号:ZL 2010 1 0124664.0

3. 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法。已授权;授权公告日期:2013717日;专利号:ZL 2011 1 0074869.7

4. 新型吡啶并硫氮七元环衍生物作为抗肿瘤药物、及其制备方法和应用。已授权;授权公告日期:201592日;专利号:ZL 2011 1 0141898.0

5. 噻唑烷酮衍生物及其在制备抗肺癌药物中的应用。已授权;授权公告日期:201457日;专利号:ZL 2012 1 0205143.7

6. 一种具有克服和避免P糖蛋白介导的肿瘤多药耐药性双重作用的金纳米药物载体。已授权;授权公告日期:20151028日;专利号:ZL 2014 1 0075010.1

7. 一种能清除全氟污染物的金纳米颗粒阵列。已授权;授权公告日期:2016127日;专利号:ZL 2014 10169811.4

8. 一种空间位阻结构单一变化的金纳米颗粒阵列及其应用。已授权;授权公告日期:20151028日;专利号:ZL 2014 1 0464969.4

9. 一种噻唑烷酮化合物及其在制备治疗铁紊乱相关疾病药物中的应用。已授权;授权公告日期:2016420日;专利号:ZL 2014 1 0698860.7

10. 一种具有表面多样性的金纳米颗粒系列化合物。已授权;授权公告日期:2019716日;专利号:ZL 2017 1 0168630.3

11. 一种具有多样化空间构型与π电子密度的配体分子化合物及其应用。已授权;授权公告日期:2019716日;专利号:ZL 2017 1 1021047.6

12. 2-(4-三氟甲基苯亚胺基)-5-(2-萘基亚甲基)噻唑烷-4-酮化合物及应用。已授权;授权公告日期:201989日;专利号:ZL 2017 1 0184406.3

13. 5-(4-羟基-3-甲氧基苯亚甲基)-2-(2-硝基苯亚胺基)噻唑烷酮及应用。已授权;授权公告日期:201989日;专利号:ZL 2017 1 0186484.7

 

科技奖励:

1. 闫兵(1/4);典型纳米材料的生物效应及调控方法原理,山东省人民政府,自然科学一等奖,2019 (闫兵;周宏钰;陈令新;江桂斌)

2. 闫兵(1/1)Shaping Activity through Structural Modification: From Small Molecules to Nanoparticles, Award for Scientific Excellence from the Division of Environmental Chemistry of the American Chemical Society, 2018 (闫兵).

 

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