【个人简介】

张秋,女,医学博士,副教授,硕士生导师

E-mail：zhangqiu@sdu.edu.cn

【主要研究方向】

从事环境毒理领域的研究，主要包括环境污染物的细胞毒性，及污染物在动物体内引发的生物效应及机制。

【学习及工作经历】

2013.05-2015.05 山东大学化学与化工学院，博士后

2010.01-2011.02 美国St. Jude儿童研究医院，访问学者

2005.06-至今 ，先后任山东大学化学与化工学院讲师、副教授; 山东大学环境科学与工程学院，副教授

2000.09-2005.07 山东大学医学院，医学博士（免疫学专业、硕博连读）

【主要论著】

36. Zhu B,Wei X,Song J,Zhang Q,Jiang W. Crystalline phase and surface coating of Al2O3 nanoparticles and their influence on the integrity and fluidity of model cell membranes. Chemosphere. 2020 Jan 8;247:125876.

35. Zhao H,Shang Q,Pan Z,Bai Y,Li Z,Zhang H,Zhang Q,Guo C,Zhang L,Wang Q. Exosomes From Adipose-Derived Stem Cells Attenuate Adipose Inflammation and Obesity Through Polarizing M2 Macrophages and Beiging in White Adipose Tissue.Diabetes. 2018 Feb;67(2):235-247.

34. Xiaoyuan Miao, Xiangfeng Leng,Qiu Zhang*. The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research. Int J Mol Sci 2017,18, 336.

33. Li W, Leng XF,Zhang Q , Zhao CF, Lv CG ,Xu TF.Nuclear localization signal of TGF-beta-inducible nuclear protein 1 mediates functions of TINP1 in suppression of the p53 signaling pathway and promotion of cell proliferation. Int J Clin Exp Med. 2017, 10(3), 4748-4755.

32. Yongyi Wei, Yang Li, Jianbo Jia, Yiguo Jiang, Bin Zhao,Qiu Zhang*, Bing Yan. Aggravated hepatotoxicity occurs in aged mice but not in young mice after oral exposure to zinc oxide nanoparticles.Nano Impact 2016, 3-4:1-11.

31. Yan Mu, Yongjin Liu, Jinbao Xiang, Qiu Zhang, Shumei Zhai, Daniel P. Russo, Hao Zhu and Xu Bai and Bing Yan*. From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor.Cell Death Dis 2016, 7: e2143.

30. Zhiping Wang, Chunhui Li, Yan Mu, Zhang Lin, Anji Yi,Qiu Zhang*, Bing Yan. Nanoadduct Relieves: Alleviation of Developmental Toxicity of Cr(VI) Due to Its Spontaneous Adsorption to Mg(OH)₂ Nanoflakes.J Hazard Mater, 2015; 287:296-305.

29. Yan Mu, Yin Liu, Liwen Li, Cong Tian, Hongyu Zhou,Qiu Zhang*, Bing Yan. The Novel Tubulin Polymerization Inhibitor MHPT Exhibits Selective Anti-tumor Activity against Rhabdomyosarcoma in vitro and in vivo.PlOS ONE, 2015; 10(3):e0121806.

28. Yin Liu, Fei Li, Ling Wu, Wenyi Wang, Hao Zhu, Qiu Zhang, Hongyu Zhou, Bing Yan*. Improving Both Aqueous Solubility and Anti-Cancer Activity by Assessing Progressive Lead Optimization Libraries.Bioorg Med Chem Lett. 2015; 25(9):1971-5.

27.Zhang Q, Zhai S, Li L, Li X, Jiang C, Zhang C, Yan B.P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model. J Pharmacol Sci. 2014; 126(1):66-76.

26. Leng X,Zhang Q*, Chen Z, Wang D.Blocking TRAIL-DR5 signaling with soluble DR5 alleviates acute kidney injury in a severely burned mouse model. Int J Clin Exp Pathol. 2014; 7(6):3460-8.

25. Jiao Q, Li L, Mu Q,Zhang Q*.Immunomodulation of nanoparticles in nanomedicine applications. Biomed Res Int. 2014; 2014:426028.

24. Zhang CK, Zhai SM, Li XE,Zhang Q, Wu L, Liu Y, Jiang CJ, Zhou HY, Li F, Zhang SS, Su GX, Zhang B, Yan B.* Synergistic Action by Multi-targeting Compounds Produces a Potent Compound Combination for Human NSCLC both in vitro and in vivo. Cell Death & Disease 2014;5:1138.

23. Li Liwen; Liu Yin;Zhang Qiu; Zhou Hongyu; Zhang Yi; Yan Bing. Comparison of Microtubule Damage-Triggered Cancer Cell Survival after Turning Kinase Dyrk1B On and Off.ACS Chemical Biology, 2014;9(3):731-42.

22. Zhang Q*,Li F. Combating P-glycoprotein-Mediated Multidrug Resistance Using Therapeutic Nanoparticles.Curr Pharm Des. 2013，19(37):6655-66.

21. Zhang Q，Zhai S,Li L,Li X,Zhou H,Liu A,Su G,Mu Q,Du Y,Yan B. Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochem Pharmacol. 2013; 86(3): 351-60.

20.Zhang Q,Liu X,Li X,Li C,Zhou H,Yan B. Antitumor activity of（2E，5Z）-5-（2-hydroxybenzylidene）-2-（（4-phenoxyphenyl）imino） thiazolidin-4-one， a novel microtubule-depolymerizing agent， in U87MG human glioblastoma cells and corresponding mouse xenograft model.J Pharmacol Sci. 2013，1(3): 223-31.

19．Sun J,Zhang Q, Wang Z, Yan B*.Effects of nanotoxicity on female reproductivity and fetal development in animal models. Int J Mol Sci. 2013;14(5): 9319-37.

18. Zhang C,Zhang Q, Zhang Y, Yan B*.Toward a Better Understanding of Pharmacokinetics of Nanomaterials. Curr Pharm Des. 2013;19(37):6667-80.

17. Leng X,Zhang Q（co-first author), Zhai X,Chen Z*.Local transplant of human umbilical cord matrix stem cells improves skin flap survival in a mouse model. Tohoku J Exp Med. 2012; 227(3): 191-7.

16. Mu QX, Su GX, Li LW, Gilbertson B, Yu L,Zhang Q, Sun Y-P, Yan B*. Size-Dependent Cell Uptake of Protein-Coated Graphene Oxide Nanosheets.ACSAppl Mater Interfaces. 2012; 4(4), 2259-66.

15. Gao NN,Zhang Q, Mu QX, Bai YH, Li LW, Zhou HY, Butch ER, Powell TB, Snyder SE, Jiang GB, and Yan B*. Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NF-κB Activation and Reduces Its Immunotoxicity.ACS Nano. 2011; 5(6), 4581- 91.

14. Li LW,Zhang Q, Liu AF, Li, XE, Zhou HY, Liu Y, Yan B*. Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule.J Am Chem Soc. 2011; 133(18), 6886-9.

13．Zhou QF, Dergunov SA, Zhang Y, Li X, Mu QX,Zhang Q, Jiang GB, Pinkhassik F, Yan B*. Safety profile and cellular uptake of biotemplated nanocapsules with nanometer-thin walls. Nanoscale.2011; 136 (3), 872-7.

12. Zhang Q, Zhou HY, Zhai SM, Yan B*. Natural Product–Inspired Synthesis of Thiazolidine and Thiazolidinone Compounds and Their Anticancer Activities.Curr Pharm Des. 2010; 16(16):1826-42.

11. Zhang Q, Zhou HY, Yan B*. Reducing Nanotube Cytotoxicity Using a Nano-Combinatorial Library Approach.Carbon Nanotubes Methods Mol Biol. 2010; 625:95-107.

10.李秀娥,高素莲,张秋*.功能化多壁碳纳米管对NHFB细胞的毒性研究.山 东 大 学 学 报 (理学版). 2010: 45(5): 6-11.

9.冷向锋,张秋*. HBV adr亚型体外感染肝细胞模型的建立.中国病理生理杂志. 2010; 26 (1): 200-2.

8.冷向锋,陈振雨,张秋*,孙汶生.慢性乙肝患者外周血单个核细胞TRAIL受体表达及其临床意义. 基础医学与临床. 2010; 30(3), 275-9.

7.冷向锋，张秋*，孙汶生，陈振雨. HBV转染对TWEAK诱导凋亡的影响及IFN-γ对凋亡的调节.中国病理生理杂志. 2010; 26 (2): 341- 4.

6．Q Zhang，Feng W, Zhou HY, Zhang B, Yan B*. Advances in Preclinical Small Molecules for the Treatment of Non-Small Cell Lung Cancer.Expert Opin Ther Patents.2009; 19(6): 731-51. 2.

5. Yu YM,Zhang Q(co-first author), Mu QX, Zhang B, Yan B*. Exploring the Immunotoxicity of Carbon Nanotubes.Nanoscale Res Lett. 2008; 3(8), 271-7.

4. Zhou H, Mu Q, Gao N, Liu A, Xing Y, Gao S, Zhang Q, Qu G, Chen Y, Liu G, Zhang B, Yan B*. A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response.Nano Letters. 2008; 8(3), 859-65.

3．高宁宁，张颖，张秋*.碳纳米管的免疫毒性研究.环境化学学报. 2008; 27(6), 835-8.

2. Liang X, Liu Y（co-first author）,Zhang Q, Gao L, Han L, Ma C, Zhang L, Chen YH, Sun W. Hepatitis B Virus Sensitizes Hepatocytes to TRAIL-Induced Apoptosis through Bax. J Immunol. 2007, 78 (1):503-10.

1.Liu YG,Liu SX,Liang XH,Zhang Q,Gao LF,Han LH,Cao YL,Hou N,Du J,Sun WS. Blockade of TRAIL pathway ameliorates HBV-induced hepatocyte apoptosis in an acute hepatitis model. Biochem Biophys Res Commun.2007, 352 (2): 329-34.

【主持、参与承担的科研项目】

1.国家重点研发计划纳米专项：水污染治理所用纳米材料的生物安全性（项目编号：2016YFA0203103，执行年限：2016.07-2021.06）、课题骨干

2.山东大学交叉学科培育项目（2016JC006）:颗粒污染物性质分析与细胞毒理研究、 联合主持

3.中国科学院B类战略性先导科技专项：“典型污染物的环境暴露与健康危害机制”，协作课题“细颗粒物引起细胞氧化应激及免疫毒性的机制及健康效应关联”（项目编号：XDB14030401，2014-2019）、课题骨干

4.中国博士后第七批特别资助（2014T70642）：不同表面修饰的碳纳米管暴露对小鼠继发乙型肝炎的影响、主持

5.国家自然科学基金青年基金（21307077）：对比羧基化多壁碳纳米管和羧基化石墨烯预暴露对乙型肝炎病毒所致肝损伤的作用研究、主持

6.山东省自然科学基金青年基金（ZR2013BQ026）：噻唑烷酮类小分子化合物选择性抗脑神经胶质瘤作用的机制研究、主持

7.教育部博士点基金（20130131120007）：羧基化多壁碳纳米管预暴露对乙型肝炎病毒感染所致小鼠肝损伤的影响及机制研究、主持

8.教育部留学回国人员基金（2014-2016）：新型噻唑烷酮化合物选择性抗脑神经胶质瘤作用的实验研究、主持

9.第54批博士后面上资助（2013M541920）：多壁碳纳米管预暴露对小鼠乙型肝炎的影响及机制研究、主持

10. 山东大学交叉学科培育项目（2012JC028）:肝癌靶向治疗的特异性表观遗传纳米药物研究、联合主持

11.国家自然科学基金重大研究计划重点项目：典型纳米材料的生物毒性效应及调控研究（课题编号：21137002，2012-2016）、课题骨干

12.国家重大基础研究（973）课题：目标污染物/纳米材料和组装界面的表征方法及污染物去除过程中的安全性评价（项目编号：2010CB933504,2010-2014）、课题骨干

13.国家自然科学基金重大培育项目：选择性治疗耐药性肺癌的噻唑烷酮类小分子探针化合物的设计、合成及其体内外抗癌活性研究与机制探讨 （项目编号90913006，执行年限：2010-2012）、主要执行人

14.山东大学自主创新基金自由探索项目（2009TS019）：新型噻唑烷酮类化合物选择性诱导非小细胞肺癌凋亡的机制研究、主持

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